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Cases may be screened using ubiquitinimmunohistochemistry but must be confi rmed by immu-nohistochemical assessment for TDP-43 protein, which istranslocated from the nucleus to the cytoplasm, ubiqui-nated, and phosphorylated (see Figure 2.17). Possible mechanisms for medication-relateddysgeusia include disruption of zinc metabolism (e.g.,by impairing absorption or facilitating chelation) andalteration of ion channels prednisone purchase canada second-messenger systems,and neurotransmitters involved in gustatory percep-tion.
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